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Article

Mortality and causes of death in families with the factor V Leiden mutation (resistance to activated protein C).

Blood - 15 Mar 1997

Hille E T, Westendorp R G, Vandenbroucke J P, Rosendaal F R

Abstract excerpt

To investigate whether resistance to activated protein C (APC resistance) because of a mutation in the factor V gene (factor V Leiden) leads to a decrease in life expectancy, we analyzed overall and cause-specific mortality in 171 parents whose offspring carried this mutation. Compared with the Dutch general population, and after adjustment for age, sex, and calendar period, we found no excess deaths in the...

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Identifiers

PMID: 9058717

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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