Article
Heritability of plasma concentrations of clotting factors and measures of a prethrombotic state in a protein C-deficient family.
Journal of thrombosis and haemostasis : JTH - 1 Feb 2004
Vossen C Y, Hasstedt S J, Rosendaal F R, Callas P W, Bauer K A, Broze G J, Hoogendoorn H, Long G L, Scott B T, Bovill E G
Abstract excerpt
BACKGROUND: Earlier studies found strong support for a genetic basis for regulation of coagulation factor levels and measures of a prethrombotic state (d-dimer, prothrombin fragment 1.2). OBJECTIVES: Estimation of how much of the variation in the levels of coagulation factors and measures of a prethrombotic state, including measures of protein C activation and inactivation, could be attributed to heritability and...
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