Article
VKORC1 mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity.
Journal of thrombosis and haemostasis : JTH - 1 Dec 2012
Hodroge A, Matagrin B, Moreau C, Fourel I, Hammed A, Benoit E, Lattard V
Abstract excerpt
BACKGROUND: The VKORC1 gene codes for the VKORC1 enzyme, which is responsible for the reduction of vitamin K epoxide into vitamin K. VKORC1 enzyme is the target of vitamin K antagonists (VKA). Twenty-eight rare single mutations in the VKORC1 coding sequence have been reported from resistant patients receiving unusually high doses of VKA to achieve therapeutic anticoagulation. OBJECTIVES: It has been suggested...
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