Article
Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis.
Lancet (London, England) - 18 Jun 1994
Zöller B, Dahlbäck B
Abstract excerpt
Resistance to activated protein C (APC) is a major cause of familial thrombophilia, and can be corrected by an anticoagulant activity expressed by purified factor V. We investigated linkage between APC resistance and the factor V gene in a large kindred with familial thrombophilia. Restriction fr...
Topics
- Alleles
- Arginine
- Base Sequence
- DNA
- DNA Primers
- Factor V
- Female
- Genetic Linkage
- Humans
- Male
- Molecular Sequence Data
- Partial Thromboplastin Time
- Pedigree
- Point Mutation
- Polymerase Chain Reaction
- Protein C
- Protein S Deficiency
- Radioimmunoassay