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Article

Activated protein C resistance: a comparison between two clotting assays and their relationship to the presence of the factor V Leiden mutation.

British journal of haematology - 1 Jun 1996

Legnani C, Palareti G, Biagi R, Coccheri S, Bernardi F, Rosendaal F R, Reitsma P H, de Ronde H, Bertina R M

Abstract excerpt

Resistance to the anticoagulant effect of activated protein C (APC resistance), a frequent abnormality in patients with a history of venous thrombosis, is known to be due, in the large majority of cases, to the presence of an abnormal factor V: the factor V Leiden. It is reasonable to surmise that screening for this abnormality should be performed with a clotting method for APC resistance, before submitting the...

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Identifiers

PMID: 8652396
DOI: 10.1046/j.1365-2141.1996.d01-1709.x

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activated protein C resistance: a comparison between two clotting assays and their relationship to the presence of the factor V Leiden mutation.PMID 8652396Read ↗

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Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.Semantic proximity Read ↗

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