Article
Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative.
American journal of medical genetics - 4 Dec 2000
Collins J S, Perry R T, Watson B, Harrell L E, Acton R T, Blacker D, Albert M S, Tanzi R E, Bassett S S, McInnis M G, Campbell R D, Go R C
Abstract excerpt
Tumor necrosis factor (TNF), a proinflammatory cytokine, may be involved in the pathogenesis of Alzheimer disease (AD) based on observations that senile plaques have been found to upregulate proinflammatory cytokines. Additionally, nonsteroidal anti-inflammatory drugs have been found to delay and prevent the onset of AD. A collaborative genome-wide scan for AD genes in 266 late-onset families implicated a 20...
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