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Tumor necrosis factor-alpha -308A/G polymorphism is associated with age at onset of Alzheimer's disease.

Mechanisms of ageing and development - 1 Jun 2006

Lio Domenico, Annoni Giorgio, Licastro Federico, Crivello Antonino, Forte Giusi Irma, Scola Letizia, Colonna-Romano Giuseppina, Candore Giuseppina, Arosio Beatrice, Galimberti Lorenza, Vergani Carlo, Caruso Calogero

Abstract excerpt

Pro-inflammatory cytokines and acute-phase proteins play an important role in Alzheimer's disease (AD) neurodegeneration, and common polymorphisms of genes controlling their production have been shown to be associated with AD. Tumor necrosis factor (TNF)-alpha is an inflammatory cytokine involved in the local immune response occurring in the central nervous system of AD patients. Genetic variation could...

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PMID: 16516271
DOI: 10.1016/j.mad.2006.01.015

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