Article
Familial late-onset Alzheimer's disease: description of an Italian family with four affected siblings and one case of early-onset dementia in the preceding generation.
Aging clinical and experimental research - 1 Oct 2016
Abbate Carlo, Arosio Beatrice, Cantatore Alessandra, Viti Niccolò, Giunco Fabrizio, Bagarolo Renzo, Nicolini Paola, Gussago Cristina, Ferri Evelyn, Casati Martina, Rossi Paolo Dionigi, Casè Alessandra, Bergamaschini Luigi, Vergani Carlo, Mari Daniela
Abstract excerpt
We describe a family composed of six siblings, four of which affected by late-onset Alzheimer's disease (LOAD). We constructed the family pedigree, evaluated mutations usually associated with early-onset Alzheimer's disease (APP, PSEN1, PSEN2), and assessed polymorphisms in the apolipoprotein E (APOE) gene and in cytokine genes that we had previously found to be associated with a higher risk of LOAD (IL-10, IL-6,...
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