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Article

Tumor Necrosis Factor α and Interleukin 10 Promoter Region Polymorphisms and Risk of Late-Onset Alzheimer Disease

1 Aug 2006

Abstract excerpt

BACKGROUND: Functional polymorphisms in tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) can affect immune response, inflammation, tissue injury, and possibly the susceptibility to Alzheimer disease (AD). OBJECTIVE: To evaluate the association between promoter region polymorphisms in the TNF-alpha and IL-10 genes and risk of late-onset AD in older white subjects. DESIGN: Community-based...

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PMID: 16908746
DOI: 10.1001/archneur.63.8.1165

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