Article
TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels.
Human mutation - 1 Jul 2005
Laws Simon M, Perneczky Robert, Wagenpfeil Stefan, Müller Ulrich, Förstl Hans, Martins Ralph N, Kurz Alexander, Riemenschneider Matthias
Abstract excerpt
Alzheimer disease (AD), vascular dementia, and stroke are all associated with inflammation though their respective initiating factors differ. Recently a polymorphism in the proinflammatory cytokine tumor necrosis factor (TNF), in association with apolipoprotein E (APOE), was reported to increase AD risk. Two SNPs, rs1799724 (-850C>T; NT_007592.14:g.22400733C>T) and rs1800629 (-308G>A;...
Topics
- Aged
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoproteins E
- Female
- Gene Frequency