Article
Virus-induced maturation and activation of autoreactive memory B cells.
The Journal of experimental medicine - 18 Dec 2000
Reed A J, Riley M P, Caton A J
Abstract excerpt
We have examined B cell populations that participate in distinct phases of the immune response to the influenza virus A/PR/8/34 hemagglutinin (HA) for their susceptibility to negative selection in mice that express the HA as a neo-self-antigen (HA104 mice). We demonstrated previously that specificity for the neo-self-HA causes a population of immunoglobulin G antibody-secreting cells, which dominate the primary...
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