Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

On the self-referential nature of naive MHC class II-restricted T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2000

Viret C, He X, Janeway C A

Abstract excerpt

The use of mutant mice expressing a normal MHC class II molecule surface level but a severely restricted self-peptide diversity (H-2Malpha(-/-)) previously revealed that T cells carrying the Ealpha(52-68)-I-A(b) complex-specific 1H3.1 TCR rely on self-peptide(s) recognition for both their peripheral persistence in irradiated hosts and their intrathymic positive selection. Here, we identify Ealpha(52-68)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens
Share to Histocompatibility Antigens Class II
Share to Interphase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Radiation Chimera

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Self Tolerance

Share to T-Lymphocyte Subsets

Share to Thymus Gland

Source

Identifiers

PMID: 11086052
DOI: 10.4049/jimmunol.165.11.6183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

On the self-referential nature of naive MHC class II-restricted T cells.PMID 11086052Read ↗

Functional and phenotypic evidence for presentation of E alpha 52-68 structurally related self-peptide(s) in I-E alpha-deficient mice.Semantic proximity Read ↗

Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide.Semantic proximity Read ↗

T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant LymphocytesSemantic proximity Read ↗

Fixed expression of single influenza virus-specific TCR chains demonstrates the capacity for TCR α- and β-chain diversity in the face of peptide-MHC class I specificity.Semantic proximity Read ↗

Age-related accumulation of T cells with markers of relatively stronger autoreactivity leads to functional erosion of T cells.Semantic proximity Read ↗

MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4+ T cells.Semantic proximity Read ↗

Learning to be tolerant: how T cells keep out of trouble.Semantic proximity Read ↗

Fixing an irrelevant TCR alpha chain reveals the importance of TCR beta diversity for optimal TCR alpha beta pairing and function of virus-specific CD8+ T cells.Semantic proximity Read ↗

A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib–restricted CD8+ regulatory T cellsSemantic proximity Read ↗

The role of T-cell receptor recognition of peptide:MHC complexes in the formation and activity of Foxp3⁺ regulatory T cells.Semantic proximity Read ↗

How the T cell repertoire becomes peptide and MHC specific.Semantic proximity Read ↗

Recognition of a specific self-peptide: self-MHC class II complex is critical for positive selection of thymocytes expressing the D10 TCR.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.