Article
Desensitization of the antigen receptor primes B cells for activation by superstimulatory influenza virus.
Journal of inflammation - 1 Jan 2000
Rott O, Charreire J, Cash E
Abstract excerpt
Interaction of the B cell receptor (BCR) with non-immunogenic receptor ligands can induce a specific state of B cell unresponsiveness as a result of receptor desensitization. Provided it is maintained over time, BCR desensitization may provide the molecular basis for clonal anergy. Using an in vi...
Topics
- Animals
- Antibodies, Anti-Idiotypic
- B-Lymphocytes
- B7-1 Antigen
- Cell Division
- Cells, Cultured
- Hemagglutinin Glycoproteins, Influenza Virus
- Histocompatibility Antigens Class II
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Phenotype
- Receptors, Antigen, B-Cell
- Receptors, Interleukin-2
