Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease.

1 Oct 1996

Abstract excerpt

We have analyzed B cell tolerance in a rheumatoid factor (RF) transgenic mouse model. The model is based on AM14, a hybridoma, originally isolated from an autoimmune MRL/lpr mouse that has an affinity and specificity typical of disease-related RFs from this strain. AM14 binds to immunoglobulin (Ig)G2a of the "a" allotype (IgG2aa) and not to IgG2ab. Thus, by crossing the transgenes onto an IgHa (BALB/c) background...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunotherapy and Immune Responses
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8879198
DOI: 10.1084/jem.184.4.1269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease.PMID 8879198Read ↗

Autoantigen-Specific B Cell Activation in FAS-Deficient Rheumatoid Factor Immunoglobulin Transgenic MiceSemantic proximity Read ↗

Activation of rheumatoid factor (RF) B cells and somatic hypermutation outside of germinal centers in autoimmune-prone MRL/lpr mice.Semantic proximity Read ↗

A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formationSemantic proximity Read ↗

A role for membrane IgD in the tolerance of pathological human rheumatoid factor B cells.Semantic proximity Read ↗

B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation.Semantic proximity Read ↗

Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity.Semantic proximity Read ↗

Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.Semantic proximity Read ↗

Failed self-tolerance and autoimmunity in IgG anti-DNA transgenic miceSemantic proximity Read ↗

Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus.Semantic proximity Read ↗

Human immunoglobulin (IgG) induced deletion of IgM rheumatoid factor B cells in transgenic mice.Semantic proximity Read ↗

The role of clonal selection and somatic mutation in autoimmunity.Semantic proximity Read ↗

A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.