Article
Influence of a V kappa 8 L chain transgene on endogenous rearrangements and the immune response to the HA(Sb) determinant on influenza virus.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1991
Carmack C E, Camper S A, Mackle J J, Gerhard W U, Weigert M G
Abstract excerpt
A rearranged murine V kappa 8/J kappa 5 L chain gene that codes for the L chain of most antibodies generated in the primary response of BALB/c mice to the antigenic site, Sb, of the hemagglutinin (HA) molecule of influenza virus A/PR/8/34 (PR8) has been cloned. Three transgenic lines were generat...
Topics
- Animals
- Antibodies, Viral
- Antibody Formation
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Cloning, Molecular
- Gene Expression
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Hemagglutinins, Viral
- Hemocyanins
- Hybridomas
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Influenza A virus
- Lipopolysaccharides
- Mice