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Article

Peripheral tolerance to an islet cell‐specific hemagglutinin transgene affects both CD4<sup>+</sup> and CD8<sup>+</sup> T cells

1 Apr 1992

Abstract excerpt

To study the basis for immunological tolerance of peripheral tissue-specific antigens, a transgenic mouse line was established that expresses the influenza hemagglutinin (HA) on pancreatic islet beta cells (Ins-HA transgenic mice). When followed up to 14 months of age, Ins-HA transgenic mice did not develop spontaneous autoimmune disease. Upon immunization with HA-expressing viruses, high titers of HA-specific...

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PMID: 1348026
DOI: 10.1002/eji.1830220421

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