Article
A single pre-B cell can give rise to antigen-specific B cells that utilize distinct immunoglobulin gene rearrangements.
The Journal of experimental medicine - 1 Sept 1990
Caton A J
Abstract excerpt
A group of hybridomas that express antibodies with related specificities for the influenza virus hemagglutinin (HA), that represent B cells that were the clonal progeny of a single pre-B cell, and that utilized distinct L chain gene rearrangements have been characterized. The clonal relationship...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Base Sequence
- Blotting, Southern
- DNA Probes
- Gene Rearrangement
- Genes, Immunoglobulin
- Hybridomas
- Immunoglobulin Heavy Chains
- Immunoglobulin J-Chains
- Immunoglobulin Variable Region
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Restriction Mapping