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Article

A single pre-B cell can give rise to antigen-specific B cells that utilize distinct immunoglobulin gene rearrangements.

The Journal of experimental medicine - 1 Sept 1990

Caton A J

Abstract excerpt

A group of hybridomas that express antibodies with related specificities for the influenza virus hemagglutinin (HA), that represent B cells that were the clonal progeny of a single pre-B cell, and that utilized distinct L chain gene rearrangements have been characterized. The clonal relationship was established by the sharing of H chain gene rearrangements at both the productive and the nonproductive alleles....

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Identifiers

PMID: 2117635
DOI: 10.1084/jem.172.3.815
PMCID: PMC2188556

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