Article
Spontaneous thrombosis in mice carrying the factor V Leiden mutation.
Blood - 15 Dec 2000
Cui J, Eitzman D T, Westrick R J, Christie P D, Xu Z J, Yang A Y, Purkayastha A A, Yang T L, Metz A L, Gallagher K P, Tyson J A, Rosenberg R D, Ginsburg D
Abstract excerpt
A polymorphism in coagulation factor V, factor V Leiden (FVL), is the major known genetic risk factor for thrombosis in humans. Approximately 10% of mutation carriers experience clinically significant thrombosis in their lifetime. In a small subset of patients, thrombosis is associated with coinheritance of other prothrombotic gene mutations. However, the potential contribution of additional genetic risk factors...
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