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Article

Thrombus stability explains the factor V Leiden paradox: a mouse model.

Blood advances - 12 Nov 2019

Shaya S A, Westrick R J, Gross P L

Abstract excerpt

Humans carrying the factor V Leiden (FVL) variant have a fivefold increased risk for venous thrombosis. However, incidence of deep vein thrombosis (DVT) is proportionally greater than that of pulmonary embolism (PE) in these individuals. This is known as the FVL paradox. We hypothesized that the rate of initial DVT development is similar in FVL and noncarriers, but thrombi in FVL carriers are more stable and...

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Identifiers

PMID: 31698465
DOI: 10.1182/bloodadvances.2019031112
PMCID: PMC6855124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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