Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice.

Critical care medicine - 1 Aug 2006

Brüggemann Lois W, Schoenmakers Saskia H H F, Groot Angelique P, Reitsma Pieter H, Spek C Arnold

Abstract excerpt

OBJECTIVE: The factor V Leiden (FVL) mutation (Arg506Glu) results in the production of an FV protein that when activated is relatively resistant to inactivation by activated protein C and thereby leads to predisposition to thrombosis. The rather high prevalence of the FVL mutation in the general...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antithrombin III
Share to Ascitic Fluid
Share to Fibrin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granulocytes

Share to Necrosis

Share to Peptide Hydrolases

Share to Peritonitis

Share to Sepsis

Source

Identifiers

PMID: 16775574
DOI: 10.1097/01.CCM.0000228918.30931.E8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16775574-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice.PMID 16775574Read ↗

Survival advantage of heterozygous factor V Leiden carriers in murine sepsis.Semantic proximity Read ↗

Spontaneous thrombosis in mice carrying the factor V Leiden mutation.Semantic proximity Read ↗

Arterial thrombosis in mice with factor V Leiden mutation.Semantic proximity Read ↗

Thrombus stability explains the factor V Leiden paradox: a mouse model.Semantic proximity Read ↗

Influence of the factor V Leiden mutation on infectious disease susceptibility and outcome: a population-based study.Semantic proximity Read ↗

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brainSemantic proximity Read ↗

Factor v Leiden mutation in severe infection and sepsis.Semantic proximity Read ↗

[Factor V Leiden mutation leads to enhanced atherosclerosis in apolipoprotein E deficient mice].Semantic proximity Read ↗

Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense.Semantic proximity Read ↗

Characterization of a mouse model for thrombomodulin deficiency.Semantic proximity Read ↗

Effect of the factor V Leiden mutation on the incidence and outcome of severe infection and sepsis.Semantic proximity Read ↗

Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.