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Article

Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin.

Circulation research - 28 Nov 2003

Dewerchin Mieke, Hérault Jean-Pascal, Wallays Goedele, Petitou Maurice, Schaeffer Paul, Millet Laurence, Weitz Jeffrey I, Moons Lieve, Collen Désiré, Carmeliet Peter, Herbert Jean-Marc

Abstract excerpt

Antithrombin (AT) inhibits thrombin and some other coagulation factors in a reaction that is dramatically accelerated by binding of a pentasaccharide sequence present in heparin/heparan-sulfate to a heparin-binding site on AT. Based on the involvement of R47 in the heparin/AT interaction and the frequent occurrence of R47 mutations in AT deficiency patients, targeted knock-in of the corresponding R48C...

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PMID: 14592998
DOI: 10.1161/01.RES.0000103634.69868.4F

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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