Article
Characterization of a mouse model for thrombomodulin deficiency.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2001
Weiler H, Lindner V, Kerlin B, Isermann B H, Hendrickson S B, Cooley B C, Meh D A, Mosesson M W, Shworak N W, Post M J, Conway E M, Ulfman L H, von Andrian U H, Weitz J I
Abstract excerpt
Mutations in the gene encoding thrombomodulin (TM), a thrombin regulator, are suspected risk factors for venous and arterial thrombotic disease. We have previously described the generation of TM(Pro/Pro) mice carrying a TM gene mutation that disrupts the TM-dependent activation of protein C. Here, it is shown that inbred C57BL/6J TM(Pro/Pro) mice exhibit a hypercoagulable state and an increased susceptibility to...
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