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Article

Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden.

Circulation - 7 May 2002

Eitzman Daniel T, Westrick Randal J, Bi Xiaoming, Manning Sara L, Wilkinson John E, Broze George J, Ginsburg David

Abstract excerpt

BACKGROUND: Factor V Leiden (FVL) is a common genetic risk factor for thrombosis in humans. The incomplete penetrance of FVL suggests important contributions from other genetic or environmental modifying factors. Variation in the expression of tissue factor pathway inhibitor (TFPI) has also been proposed as a risk factor for venous thrombosis and has been shown to enhance the prothrombotic effect of FVL in vitro....

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Source

Identifiers

PMID: 11994245
DOI: 10.1161/01.cir.0000017361.39256.82

Genes

TFPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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