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Article

[Factor V Leiden mutation leads to enhanced atherosclerosis in apolipoprotein E deficient mice].

Zhonghua xin xue guan bing za zhi - 1 Jan 2009

Shen Yue-chun, Lu Dong-feng, Wu Jun, Pan Jie-zhen, Zhao Chao-chen, Hu De-xi, Li Jun

Abstract excerpt

OBJECTIVE: Factor V Leiden (FvL) causing activated protein C resistance is a genetic risk factor for venous thrombosis in humans, and it's effect on atherosclerosis is controversial. We evaluated the effect of FvL mutation on atherosclerosis in apolipoprotein E deficient mice fed with normal diet. METHODS: Degree of atherosclerosis and tissue fibrin deposition were determined in Fv+/+ApoE-/-, FvQ/+ApoE-/- and...

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Identifiers

PMID: 19671356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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