Article

A sensitized mutagenesis screen in Factor V Leiden mice identifies novel thrombosis suppressor loci

2016-10-16

Abstract excerpt

Factor V Leiden ( F5 L ) is a common genetic risk factor for venous thromboembolism in humans. We conducted a sensitized ENU mutagenesis screen for dominant thrombosuppressor genes based on perinatal lethal thrombosis in mice homozygous for F5 L ( F5 L/L ) and haploinsufficient for tissue factor pathway inhibitor ( Tfpi +/− ). F8 deficiency enhanced survival of F5 L/L Tfpi +/− mice, demonstrating that...

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Literature Corpus work: 71fc3219-375e-5780-b1a9-95fc4e997783
DOI: 10.1101/080432

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