Article
Axonal transport defects are a common phenotype in Drosophila models of ALS.
Human molecular genetics - 15 Jun 2016
Baldwin Katie R, Godena Vinay K, Hewitt Victoria L, Whitworth Alexander J
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons resulting in a catastrophic loss of motor function. Current therapies are severely limited owing to a poor mechanistic understanding of the pathobiology. Mutations in a large number of genes have now been linked to ALS, including SOD1, TARDBP (TDP-43), FUS and C9orf72. Functional analyses of these genes and their pathogenic...
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