Article
The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1.
Current biology : CB - 18 Feb 2013
Barlan Kari, Lu Wen, Gelfand Vladimir I
Abstract excerpt
Kinesin-1 is a major microtubule motor that drives transport of numerous cellular cargoes toward the plus ends of microtubules. In the cell, kinesin-1 exists primarily in an inactive, autoinhibited state, and motor activation is thought to occur upon binding to cargo through the C terminus. Using RNAi-mediated depletion in Drosophila S2 cells, we demonstrate that kinesin-1 requires ensconsin (MAP7, E-MAP-115), a...
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