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Article

A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation.

The Journal of cell biology - 1 Feb 2017

Neisch Amanda L, Neufeld Thomas P, Hays Thomas S

Abstract excerpt

Autophagy plays an essential role in the cellular homeostasis of neurons, facilitating the clearance of cellular debris. This clearance process is orchestrated through the assembly, transport, and fusion of autophagosomes with lysosomes for degradation. The motor protein dynein drives autophagosome motility from distal sites of assembly to sites of lysosomal fusion. In this study, we identify the scaffold protein...

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Source

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Identifiers

PMID: 28100687
DOI: 10.1083/jcb.201606082
PMCID: PMC5294782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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