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Article

PTP-3 phosphatase promotes intramolecular folding of SYD-2 to inactivate kinesin-3 UNC-104 in neurons.

Molecular biology of the cell - 15 Dec 2020

Muniesh Muthaiyan Shanmugam, Barmaver Syed Nooruzuha, Huang Hsin-Yi, Bayansan Odvogmed, Wagner Oliver Ingvar

Abstract excerpt

UNC-104 is the Caenorhabditis elegans homolog of kinesin-3 KIF1A known for its fast shuffling of synaptic vesicle protein transport vesicles in axons. SYD-2 is the homolog of liprin-α in C. elegans known to activate UNC-104; however, signals that trigger SYD-2 binding to the motor remain unknown. Because SYD-2 is a substrate of PTP-3/LAR PTPR, we speculate a role of this phosphatase in SYD-2-mediated motor...

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Identifiers

PMID: 33147118
DOI: 10.1091/mbc.E19-10-0591
PMCID: PMC7927192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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