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Article

The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini.

Neuron - 26 Apr 2012

Lloyd Thomas E, Machamer James, O'Hara Kathleen, Kim Ji Han, Collins Sarah E, Wong Man Y, Sahin Brooke, Imlach Wendy, Yang Yunpeng, Levitan Edwin S, McCabe Brian D, Kolodkin Alex L

Abstract excerpt

p150(Glued) is the major subunit of dynactin, a complex that functions with dynein in minus-end-directed microtubule transport. Mutations within the p150(Glued) CAP-Gly microtubule-binding domain cause neurodegenerative diseases through an unclear mechanism. A p150(Glued) motor neuron degenerative disease-associated mutation introduced into the Drosophila Glued locus generates a partial loss-of-function allele...

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Identifiers

PMID: 22542187
DOI: 10.1016/j.neuron.2012.02.026
PMCID: PMC3353876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini.PMID 22542187Read ↗

Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor.Semantic proximity Read ↗

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Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactinSemantic proximity Read ↗

Dynactin p150Glued–Deficiency in Midbrain Dopaminergic Neurons Leads to Progressive Neurodegeneration and Endoplasmic Reticulum DysfunctionSemantic proximity Read ↗

Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport.Semantic proximity Read ↗

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