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Article

Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women.

Metabolism: clinical and experimental - 1 Nov 2000

Kauwell G P, Wilsky C E, Cerda J J, Herrlinger-Garcia K, Hutson A D, Theriaque D W, Boddie A, Rampersaud G C, Bailey L B

Abstract excerpt

Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --> T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease. A controlled metabolic study (14 weeks) using a depletion/repletion protocol was performed in women (aged 60 to 85 years, N = 33)...

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Identifiers

PMID: 11092508
DOI: 10.1053/meta.2000.16555

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women.PMID 11092508Read ↗

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MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation.Semantic proximity Read ↗

Genetic polymorphisms and folate status.Semantic proximity Read ↗

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