Article
Methylenetetrahydrofolate reductase 677C-->T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial.
The American journal of clinical nutrition - 1 Jul 2002
Ashfield-Watt Pauline A L, Pullin Catherine H, Whiting Jane M, Clark Zoë E, Moat Stuart J, Newcombe Robert G, Burr Michael L, Lewis Malcolm J, Powers Hilary J, McDowell Ian F W
Abstract excerpt
BACKGROUND: Low folate status and elevated plasma homocysteine are associated with increased risk of neural tube defects and cardiovascular disease. Homocysteine responses to folate may be influenced by genetic variants in folate metabolism. OBJECTIVE: We determined the effect of folate-enhancing dietary interventions on plasma folate and plasma total homocysteine (tHcy) with respect to the...
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