Article
The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women.
The Journal of nutrition - 1 May 2005
Davis Steven R, Quinlivan Eoin P, Shelnutt Karla P, Maneval David R, Ghandour Haifa, Capdevila Antonieta, Coats Bonnie S, Wagner Conrad, Selhub Jacob, Bailey Lynn B, Shuster Jonathan J, Stacpoole Peter W, Gregory Jesse F
Abstract excerpt
Whether folate status and the methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism interact to affect methionine-cycle metabolite concentrations is uncertain. We evaluated the effects of dietary folate restriction on relations among folate status indices and plasma concentrations of methionine cycle metabolites in women with the MTHFR 677 C/C and T/T genotypes. Healthy, normohomocysteinemic women (n...
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