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Article

Clinical utility of genotyping the 677C>T variant of methylenetetrahydrofolate reductase in humans is decreased in the post-folic acid fortification era.

The Journal of nutrition - 1 Jan 2009

Tsai Michael Y, Loria Catherine M, Cao Jing, Kim Yongin, Siscovick David, Schreiner Pamela J, Hanson Naomi Q

Abstract excerpt

Moderate hyperhomocysteinemia is associated with many diseases. Major factors affecting plasma total homocysteine (tHcy) concentrations include folate concentrations and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene. Because U.S.-mandated fortification of grain products with folic acid has improved folate and tHcy status in Americans, we investigated the effect of the MTHFR 677C>T variant...

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Identifiers

PMID: 19056652
DOI: 10.3945/jn.108.096511
PMCID: PMC2646209

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinical utility of genotyping the 677C>T variant of methylenetetrahydrofolate reductase in humans is decreased in the post-folic acid fortification era.PMID 19056652Read ↗

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