Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype.

The Journal of nutrition - 1 Jan 2008

Solis Claudia, Veenema Kristin, Ivanov Alexandre A, Tran Sally, Li Rui, Wang Wei, Moriarty David J, Maletz Charles V, Caudill Marie A

Abstract excerpt

Since the establishment of the 1998 folate recommended dietary allowance (RDA), the methylenetetrahydrofolate reductase (MTHFR) 677C-->T variant has emerged as a strong modifier of folate status. This controlled feeding study investigated the adequacy of the RDA, 400 microg/d as dietary folate equivalents (DFE), for Mexican American men with the MTHFR 677CC or TT genotype. Because of the interdependency between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Choline
Share to Diet

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Folic Acid

Share to Folic Acid Deficiency

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Mexican Americans

Share to Vitamin B Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 18156406
DOI: 10.1093/jn/138.1.67
PMCID: PMC2646848

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype.PMID 18156406Read ↗

Methylenetetrahydrofolate reductase 677C-->T variant modulates folate status response to controlled folate intakes in young women.Semantic proximity Read ↗

Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genotype.Semantic proximity Read ↗

Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women.Semantic proximity Read ↗

Does the MTHFR 677C-->T variant affect the Recommended Dietary Allowance for folate in the US population?Semantic proximity Read ↗

Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic subgroup of folate-compromised men.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women.Semantic proximity Read ↗

Ethnicity and race influence the folate status response to controlled folate intakes in young women.Semantic proximity Read ↗

Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteine.Semantic proximity Read ↗

Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype.Semantic proximity Read ↗

Adequate Intake levels of choline are sufficient for preventing elevations in serum markers of liver dysfunction in Mexican American men but are not optimal for minimizing plasma total homocysteine increases after a methionine load.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase 677C-->T polymorphism affects DNA methylation in response to controlled folate intake in young women.Semantic proximity Read ↗

Clinical utility of genotyping the 677C>T variant of methylenetetrahydrofolate reductase in humans is decreased in the post-folic acid fortification era.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.