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Article

Methylenetetrahydrofolate reductase 677C-->T polymorphism affects DNA methylation in response to controlled folate intake in young women.

The Journal of nutritional biochemistry - 1 Sept 2004

Shelnutt Karla P, Kauwell Gail P A, Gregory Jesse F, Maneval David R, Quinlivan Eoin P, Theriaque Douglas W, Henderson George N, Bailey Lynn B

Abstract excerpt

DNA methylation is critical for normal genomic structure and function and is dependent on adequate folate status. A polymorphism (677C-->T) in a key folate enzyme, methylenetetrahydrofolate reductase (MTHFR), may impair DNA methylation when folate intake is inadequate and may increase the risk of reproductive abnormalities. The present study was designed to evaluate the effect of the MTHFR 677C-->T polymorphism...

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Source

Identifiers

PMID: 15350988
DOI: 10.1016/j.jnutbio.2004.04.003

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylenetetrahydrofolate reductase 677C-->T polymorphism affects DNA methylation in response to controlled folate intake in young women.PMID 15350988Read ↗

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