Article
The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 1997
Malinow M R, Nieto F J, Kruger W D, Duell P B, Hess D L, Gluckman R A, Block P C, Holzgang C R, Anderson P H, Seltzer D, Upson B, Lin Q R
Abstract excerpt
Elevated concentration of plasma total homocysteine (tHcy) is a common risk factor for arterial occlusive diseases. Folic acid (FA) supplementation usually lowers tHcy levels, but initial tHcy and vitamin levels, multivitamin use, and polymorphisms in the gene for 5, 10-methylenetetrahydrofolate reductase (MTHFR) may contribute to variability in reduction. We tested the effects of a 3-week daily intake of 1 or 2...
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