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Article

Histone deacetylase activity is required for the induction of the MyoD muscle cell lineage in Xenopus.

Biological chemistry - 1 Jan 2000

Steinbac O C, Wolffe A P, Rupp R A

Abstract excerpt

Acetylation of nucleosome core histones, which is positively correlated with transcriptional activity, is developmentally regulated in Xenopus. Here we have used the specific histone deacetylase (HDAC)-inhibitor trichostatin A (TSA) to induce precocious histone hyperacetylation in the early frog embryo in order to investigate the potential role of the endogenous changes in chromatin acetylation for the temporally...

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Identifiers

PMID: 11076034
DOI: 10.1515/BC.2000.124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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