Article
Activation of muscle genes without myogenesis by ectopic expression of MyoD in frog embryo cells.
Nature - 13 Sept 1990
Hopwood N D, Gurdon J B
Abstract excerpt
The sequence-specific DNA-binding protein, MyoD, can activate muscle-specific gene expression in some cells in culture. Xenopus MyoD (XMyoD) transcription is activated as a consequence of mesoderm induction in the early myotomes, from which the axial musculature develops. XMyoD RNA accumulates about two hours before muscle-specific actin transcripts first appear, and so is expressed at the right time and in the...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Differentiation
- DNA-Binding Proteins
- Gene Expression
- Mesoderm
- Microinjections
- Molecular Sequence Data
- Muscle Proteins
- Muscles
- Mutation