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The Effects of Trichostatin A on mRNA Expression of Chromatin Structure-, DNA Methylation-, and Development-Related Genes in Cloned Mouse Blastocysts

3 Feb 2008

Abstract excerpt

Trichostatin A (TSA) is the most potent histone deacetylase (HDAC) inhibitor known. We previously reported that treatment of mouse somatic cell nuclear-transferred (SCNT) oocytes with TSA significantly increased the blastocyst rate, blastocyst cell number, and full-term development. How TSA enhances the epigenetic remodeling ability of somatic nuclei and the expression of development-related genes, however, is...

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Identifiers

PMID: 18241125
DOI: 10.1089/clo.2007.0066

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The Effects of Trichostatin A on mRNA Expression of Chromatin Structure-, DNA Methylation-, and Development-Related Genes in Cloned Mouse BlastocystsPMID 18241125Read ↗

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