Article
Histone deacetylase 7 (HDAC7) regulates myocyte migration and differentiation.
Biochimica et biophysica acta - 1 Oct 2010
Gao Chengzhuo, Liu Yu, Lam Minh, Kao Hung-Ying
Abstract excerpt
Class IIa HDACs including HDAC7 play a role in gene expression, cell differentiation, and animal development through their association with transcription factors such as myogenic enhancer factors 2 (MEF2s). In this study, we show that endogenous HDAC7 localizes to both the nucleus and the cytoplasm of C2C12 myoblasts but is exclusively retained in the cytoplasm of myotubes after completion of differentiation...
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