Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

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Article

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

The Journal of biological chemistry - 5 Oct 1990

Yoshida M, Kijima M, Akita M, Beppu T

Abstract excerpt

(R)-Trichostatin A (TSA) is a Streptomyces product which causes the induction of Friend cell differentiation and specific inhibition of the cell cycle of normal rat fibroblasts in the G1 and G2 phases at the very low concentrations. We found that TSA caused an accumulation of acetylated histone s...

Topics

Acetates
Acetylation
Animals
Antifungal Agents
Antimetabolites, Antineoplastic
Cell Line
Cell Survival
Drug Resistance
Histone Deacetylase Inhibitors
Histones
Hydroxamic Acids
Kinetics
Mice
Mutation
Streptomyces

Source

Open in PubMed

Identifiers

PMID: 2211619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2211619-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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