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Article

Early embryonic lethality due to targeted inactivation of DNA ligase III.

Molecular and cellular biology - 1 May 2006

Puebla-Osorio Nahum, Lacey Devin B, Alt Frederick W, Zhu Chengming

Abstract excerpt

DNA ligases catalyze the joining of strand breaks in the phosphodiester backbone of duplex DNA and play essential roles in DNA replication, recombination, repair, and maintenance of genomic integrity. Three mammalian DNA ligase genes have been identified, and their corresponding ligases play distinct roles in DNA metabolism. DNA ligase III is proposed to be involved in the repairing of DNA single-strand breaks,...

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Source

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Identifiers

PMID: 16648486
DOI: 10.1128/MCB.26.10.3935-3941.2006
PMCID: PMC1489003

Genes

LIG3
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Early embryonic lethality due to targeted inactivation of DNA ligase III.PMID 16648486Read ↗

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