Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered DNA ligase activity in human disease

10 Sept 2019

Abstract excerpt

The joining of interruptions in the phosphodiester backbone of DNA is critical to maintain genome stability. These breaks, which are generated as part of normal DNA transactions, such as DNA replication, V(D)J recombination and meiotic recombination as well as directly by DNA damage or due to DNA damage removal, are ultimately sealed by one of three human DNA ligases. DNA ligases I, III and IV each function in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to DNA Repair Mechanisms
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31630206
DOI: 10.1093/mutage/gez026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered DNA ligase activity in human diseasePMID 31630206Read ↗

Ligase IV syndrome.Semantic proximity Read ↗

DNA ligase IV syndrome; a review.Semantic proximity Read ↗

Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndromeSemantic proximity Read ↗

Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells.Semantic proximity Read ↗

NHEJ deficiency and disease.Semantic proximity Read ↗

Omenn syndrome is associated with mutations in DNA ligase IV.Semantic proximity Read ↗

Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeuticsSemantic proximity Read ↗

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency.Semantic proximity Read ↗

Rare variants of DNA ligase 1 show distinct mechanisms of deficiencySemantic proximity Read ↗

Completion of base excision repair by mammalian DNA ligases.Semantic proximity Read ↗

Mammalian DNA ligases.Semantic proximity Read ↗

Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.