Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III.

Molecular and cellular biology - 1 Jan 1994

Caldecott K W, McKeown C K, Tucker J D, Ljungquist S, Thompson L H

Abstract excerpt

XRCC1, the human gene that fully corrects the Chinese hamster ovary DNA repair mutant EM9, encodes a protein involved in the rejoining of DNA single-strand breaks that arise following treatment with alkylating agents or ionizing radiation. In this study, a cDNA minigene encoding oligohistidine-tagged XRCC1 was constructed to facilitate affinity purification of the recombinant protein. This construct, designated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to DNA, Complementary

Share to Molecular Sequence Data

Share to Mutation

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 8264637
DOI: 10.1128/mcb.14.1.68-76.1994
PMCID: PMC358357

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III.PMID 8264637Read ↗

Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells.Semantic proximity Read ↗

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.Semantic proximity Read ↗

Construction of human XRCC1 minigenes that fully correct the CHO DNA repair mutant EM9.Semantic proximity Read ↗

Mitochondrial DNA ligase III function is independent of Xrcc1.Semantic proximity Read ↗

Altered DNA ligase III activity in the CHO EM9 mutant.Semantic proximity Read ↗

XRCC1 and DNA polymerase beta interaction contributes to cellular alkylating-agent resistance and single-strand break repair.Semantic proximity Read ↗

XRCC1-DNA polymerase beta interaction is required for efficient base excision repair.Semantic proximity Read ↗

DNA damage levels and biochemical repair capacities associated with XRCC1 deficiency.Semantic proximity Read ↗

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.Semantic proximity Read ↗

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells.Semantic proximity Read ↗

Partial correction of the single-strand break repair defect in the CHO mutant EM9 by electroporated recombinant XRCC1 protein.Semantic proximity Read ↗

Micronuclei in EM9 cells expressing polymorphic forms of human XRCC1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.