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Article

Completion of base excision repair by mammalian DNA ligases.

Progress in nucleic acid research and molecular biology - 1 Jan 2001

Tomkinson A E, Chen L, Dong Z, Leppard J B, Levin D S, Mackey Z B, Motycka T A

Abstract excerpt

Three mammalian genes encoding DNA ligases--LIG1, LIG3, and LIG4--have been identified. Genetic, biochemical, and cell biology studies indicate that the products of each of these genes play a unique role in mammalian DNA metabolism. Interestingly, cell lines deficient in either DNA ligase I (46BR.1G1) or DNA ligase III (EM9) are sensitive to simple alkylating agents. One interpretation of these observations is...

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Identifiers

PMID: 11554294
DOI: 10.1016/s0079-6603(01)68097-8

Genes

LIG1
LIG3
LIG4
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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