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Article

DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair.

Nature - 10 Mar 2011

Gao Yankun, Katyal Sachin, Lee Youngsoo, Zhao Jingfeng, Rehg Jerold E, Russell Helen R, McKinnon Peter J

Abstract excerpt

DNA replication and repair in mammalian cells involves three distinct DNA ligases: ligase I (Lig1), ligase III (Lig3) and ligase IV (Lig4). Lig3 is considered a key ligase during base excision repair because its stability depends upon its nuclear binding partner Xrcc1, a critical factor for this DNA repair pathway. Lig3 is also present in the mitochondria, where its role in mitochondrial DNA (mtDNA) maintenance...

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PMID: 21390131
DOI: 10.1038/nature09773
PMCID: PMC3079429

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