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Article

The contribution of somatic hypermutation to the diversity of serum immunoglobulin: dramatic increase with age.

Immunity - 1 Sept 2000

Williams G T, Jolly C J, Köhler J, Neuberger M S

Abstract excerpt

Although somatic mutation contributes to the diversity of only a minor fraction of B cells in mouse spleen or blood, its contribution to the diversity of serum immunoglobulin is unknown. We have devised an immunoassay to monitor mutated antibodies in serum using a monoclonal antibody that recognizes a VK only when mutated at its major intrinsic hot spot. Mutation makes essentially no contribution to the diversity...

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Identifiers

PMID: 11021538
DOI: 10.1016/s1074-7613(00)00040-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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