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Article

Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine.

The Journal of experimental medicine - 13 Feb 2012

Lindner Cornelia, Wahl Benjamin, Föhse Lisa, Suerbaum Sebastian, Macpherson Andrew J, Prinz Immo, Pabst Oliver

Abstract excerpt

Intestinal immunoglobulin A (IgA) ensures host defense and symbiosis with our commensal microbiota. Yet previous studies hint at a surprisingly low diversity of intestinal IgA, and it is unknown to what extent the diverse Ig arsenal generated by somatic recombination and diversification is actually used. In this study, we analyze more than one million mouse IgA sequences to describe the shaping of the intestinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunospot Assay

Share to Immunoglobulin A

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Share to Microscopy, Fluorescence

Share to Somatic Hypermutation, Immunoglobulin

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Source

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Identifiers

PMID: 22249449
DOI: 10.1084/jem.20111980
PMCID: PMC3280880

Provenance

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