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Article

Trends in Antibody Sequence Changes during the Somatic Hypermutation Process

1 Jul 2006

Abstract excerpt

Probable germline gene sequences from thousands of aligned mature Ab sequences are inferred using simple computational matching to known V(D)J genes. Comparison of the germline to mature sequences in a structural region-dependent fashion allows insights into the methods that nature uses to mature Abs during the somatic hypermutation process. Four factors determine the residue type mutation patterns: biases in the...

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PMID: 16785529
DOI: 10.4049/jimmunol.177.1.333

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